Yes it does. Astute Graphics is actively working to rebuild its software to run natively on Apple computers using the Apple Silicon M1 chip. In the meantime, the Astute Manager and the plugins will run on Apple M1 without issue, as long as you run Illustrator under the Rosetta 2 emulation.
Operating plugins using Apple's Rosetta 2 technology
Apple developed Rosetta 2 technology (present on all M1-based Mac computers) to allow software built for Intel-based Macs to work on its latest hardware.
On 8 June, Adobe released Illustrator 2021 (v25.3) which is both Apple M1 (ARM) and Intel hardware native. At present, Astute Graphics' plugins are not yet M1 native. Therefore, if attempting to run Illustrator 2021 (v25.3) in native M1 mode with the plugins installed, the following dialogue will be displayed:
As instructed, launch Illustrator in Intel Emulation mode to use the plugin.
How to run Illustrator 2021 (v25.3+) under Rosetta Intel emulation
To force Adobe Illustrator 2021 (v25.3+) to run Intel code through Rosetta emulation instead of native Apple M1 hardware, it requires ticking a box in the Illustrator 2021 macOS "Get Info" window.
Quit Illustrator 2021
Open the Applications > Adobe Illustrator 2021 > ... folder
Right-click the Adobe Illustrator 2021 icon in the Finder
Select Get Info
In the info window, tick Open using Rosetta
Close the info window
Reload Illustrator 2021
All previous versions of Adobe Illustrator 2021 run on Apple M1 hardware under Rosetta 2 emulation by default and no further action is required.
Astute Manager and Apple M1 computers
The Astute Manager runs successfully and seamlessly on Apple M1 hardware under Rosetta 2 emulation. Users do not have to take any special steps or actions to ensure this.
Astute Graphics is currently working on development of Astute Manager v3 which will bring numerous enhancements as well as M1 native operation. We currently anticipate a Q3 2021 release date.
Watch this space
All customers will be notified when M1 native plugins becomes available.