With the release of Astute Manager v3.5, the following folders on macOS are no longer valid for plugin install paths (locations):
Desktop
Downloads
Documents
It is no longer possible to manually specify these folders, or sub-folders of the above, in the Astute Manager.
If you have specified these locations prior to updating to Astute Manager v3.5, you will be required to change the locations via the Astute Manager > Settings page and then manually remove any plugins from these folders or sub-folders.